Adane et al. 2015
Pharmacokinetics of Vancomycin in Extremely Obese Patients with Suspected or Confirmed Staphylococcus aureus Infections
Pharmacotherapy · 10.1002/phar.1531
Structure
A one-compartment model, driven by weight and creatinine clearance.
Study population
Obese patients — United States and North America. Fitted to 31 patients and 93 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 43 (IQR 38.5–53) yr |
| Weight | 147.9 (IQR 142.8–178.3) kg |
| BMI | 49.5 (IQR 44.3–54.8) kg/m² |
| CrCl | 124.8 (IQR 106–133.9) mL/min |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = CrCl \cdot \frac{6.54 \cdot 1.73}{125 \cdot BSA}
V_1 = 0.51 \cdot Weight
Implementation notes
Extremely obese cohort (BMI ≥ 40). Clearance scales with BSA-standardized Cockcroft-Gault CrCl (Du Bois BSA); volume with total body weight.