Terms of Use

2. Educational and research use only

Chorus is provided strictly for educational and research purposes. It is an experimental tool: simulation results it generates are not clinically validated. This application is not a medical device and is not intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease.

Do not use Chorus in actual patient care. Its outputs must never guide real-world dosing — not even as a cross-check. Real clinical decisions must be made with validated clinical decision support tools and standard institutional protocols, not with this application.

3. Known limitations

By using this tool, you acknowledge the following explicit limitations:

• Chorus models adults only (≥ 18 years of age). Pediatric pharmacokinetics are not modeled.
• It does not support renal replacement therapies, including continuous renal replacement therapy (CRRT), intermittent hemodialysis (HD), or peritoneal dialysis (PD).
• Simulation results are theoretical mathematical estimates derived from population pharmacokinetic models. They do not guarantee actual physiological or clinical outcomes.
• How a published model performs outside the cohort it was derived in is rarely established, and a patient who does match a cohort description may still have atypical kinetics.

4. No clinical validation

Neither the ensemble methodology nor the regimen search has been independently validated for clinical efficacy or patient safety. Use is at the user's own risk.

5. Disclaimer of warranties

Chorus is provided on an "as-is" and "as-available" basis. The developers expressly disclaim all warranties, express or implied, including but not limited to implied warranties of merchantability, fitness for a particular purpose, and non-infringement. No warranty is made that the application will be error-free, uninterrupted, or produce accurate results for any given scenario.

6. Limitation of liability

Under no circumstances shall the creators, developers, or maintainers of Chorus be liable for any direct, indirect, incidental, special, consequential, or exemplary damages — including adverse patient outcomes, clinical error, injury, or death — arising from use of or reliance on this application.

By using Chorus, you agree to defend, indemnify, and hold harmless its developers from any claims, liabilities, damages, or expenses arising from your use of the application or violation of these Terms.

7. User data responsibility

Because the simulation runs entirely in your browser, you are solely responsible for the security of the device and browser you use it on. A scenario exists in the open tab and is discarded when you close or reload it. The developers have no access to what you enter and cannot recover it under any circumstances.

8. Modifications and availability

The developers reserve the right to modify, update, suspend, or discontinue the application at any time without notice. No obligation exists to update the models or methods.