Aljutayli et al. 2022
Pharmacokinetic equations versus Bayesian guided vancomycin monitoring: Pharmacokinetic model and model-informed precision dosing trial simulations
Clinical and Translational Science · 10.1111/cts.13210
Structure
A one-compartment model, driven by weight and creatinine clearance.
Study population
General patients — Canada and North America. Fitted to 116 patients and 326 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 67.8 ± 11 yr |
| Weight | 72 ± 8.6 kg |
| BMI | 24.2 ± 3.1 kg/m² |
| SCr | 1 ± 0.5 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = CrCl \cdot \frac{4.16}{84.0}
V_1 = 102.46 \cdot \frac{Weight}{70}
Implementation notes
General-population one-compartment model (normal-weight cohort). CL scales linearly with Cockcroft-Gault CrCl; V with total body weight.