Bae et al. 2019
Application of Pharmacometrics in Pharmacotherapy: Open-Source Software for Vancomycin Therapeutic Drug Management
Pharmaceutics · 10.3390/pharmaceutics11050224
Structure
A two-compartment model, driven by weight and creatinine clearance.
Study population
General patients — Korea and Asia. Fitted to 220 patients and 1,020 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 63 (21–98) yr |
| Weight | 61.6 (30–126.7) kg |
| CrCl | 77 (4.57–279) mL/min |
| SCr | 1.7 (0.2–13.3) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 2.82 \cdot \left(\frac{CrCl}{72}\right)^{0.836}
V_1 = 31.8
V_2 = 75.4 \cdot \frac{Weight}{60}
Q = 11.7
Implementation notes
Korean general-population TDM model. HD and CRRT clearance covariates excluded; implemented for non-RRT patients.