Bang et al. 2021
Development of a new pharmacokinetic model for target-concentration controlled infusion of vancomycin in critically ill patients
Clinical and Experimental Pharmacology and Physiology · 10.1111/1440-1681.13597
Structure
A three-compartment model, driven by weight, age and ideal body weight.
Study population
Critically ill patients — Korea and Asia. Fitted to 22 patients and 197 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 67.5 (36–87) yr |
| Weight | 62.9 (47.1–90.6) kg |
| BMI | 23.7 (17.7–29.5) kg/m² |
| CrCl | 101.4 (52.3–160.9) mL/min |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = \begin{cases} (0.0143 + \frac{Weight}{53} \cdot 0.0271) \cdot 60 & \text{Age} > 65 \\ (0.0349 + \frac{Weight}{53} \cdot 0.0271) \cdot 60 & \text{Age} \leq 65 \end{cases}
V_1 = 4.04 + \left(\frac{IBW}{59}\right)^{4.21}
V_2 = 16.6
V_3 = 42.6 + \left(\frac{IBW}{59}\right)^{12.7}
Q_2 = 17.64
Q_3 = 4.896
Implementation notes
Three-compartment model for critically ill patients (target-controlled infusion). CL steps with age (>65 vs ≤65); volumes scale with ideal body weight. Residual widened from the paper's tight TCI value for stable real-world fitting.