Brooks et al. 2026 (low SCr)
Leveraging real-world data to create vancomycin population pharmacokinetic models in younger adults and patients with low serum creatinine
Journal of the American Pharmacists Association Pharmacotherapy · 10.1016/j.japhar.2025.100026
Structure
A two-compartment model, driven by weight, age, sex and serum creatinine.
Study population
General patients — United States and North America. Fitted to 2,354 patients and 6,729 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 60 (21–91) yr |
| Weight | 68 (35–155) kg |
| BMI | 24.4 (14–57) kg/m² |
| CrCl | 161 (56–539) mL/min |
| SCr | 0.5 (0.2–0.8) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 7.055 \cdot \left(\frac{FFM}{55}\right)^{0.78} \cdot \left(\frac{\max(SCr, 0.3382)}{0.4}\right)^{-0.2209} \cdot Age_{effect} \cdot Sex_{effect,CL}
Age_{effect} = \frac{Age^{-2.285}}{Age^{-2.285} + 78.42^{-2.285}} \Big/ \frac{35.8^{-2.285}}{35.8^{-2.285} + 78.42^{-2.285}}
Sex_{effect,CL} = 0.904 \text{ if Male, else } 1.0
V_1 = 66.15 \cdot \frac{FFM}{55} \cdot Sex_{effect,V1}
Sex_{effect,V1} = 0.863 \text{ if Male, else } 1.0
V_2 = 56.76 \cdot \frac{FFM}{55}
Q = 2.900
Implementation notes
Model explicitly developed for patients with low serum creatinine (<0.8 mg/dL). Uses measured SCr directly, bounded to a data-derived minimum of 0.3382 mg/dL.