Buelga et al. 2005
Population Pharmacokinetic Analysis of Vancomycin in Patients with Hematological Malignancies
Antimicrobial Agents and Chemotherapy · 10.1128/AAC.49.12.4934-4941.2005
Structure
A one-compartment model, driven by weight and creatinine clearance.
Study population
Hematologic malignancy patients — Spain and Europe. Fitted to 215 patients and 1,004 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 51.5 ± 15.9 yr |
| Weight | 64.7 ± 11.3 kg |
| CrCl | 89.4 ± 39.2 mL/min |
| SCr | 0.9 ± 0.4 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 1.08 \cdot CrCl \cdot \frac{60}{1000}
V_1 = 0.98 \cdot Weight
Implementation notes
Hematological-malignancy cohort with high vancomycin clearance. CL scales with Cockcroft-Gault CrCl (conventional SCr, total body weight); V with total body weight.