Bury et al. 2019
The effect of neutropenia on the clinical pharmacokinetics of vancomycin in adults
European Journal of Clinical Pharmacology · 10.1007/s00228-019-02657-6
Structure
A two-compartment model, driven by fat-free mass, creatinine clearance and neutropenia.
Study population
General and Mixed patients — Netherlands and Europe. Fitted to 116 patients and 742 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 61.4 ± 13.4 yr |
| BMI | 25.5 (IQR 22.6–28.4) kg/m² |
| CrCl | 92.7 (IQR 65.7–131) mL/min |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 3.22 \cdot (1 + 0.00834 \cdot (CrCl - 104)) \cdot 1.277^{Neut}
V_1 = 45.8 \cdot \frac{FFM}{57.2}
V_2 = 51.7 \cdot \frac{FFM}{57.2}
Q = 4.03 \cdot \left(\frac{FFM}{57.2}\right)^{0.75}
Implementation notes
Hematology/oncology cohort; sizes scaled to fat-free mass. Neutropenia (from tag) raises clearance 27.7%.