Cheng et al. 2022
Population Pharmacokinetics of Vancomycin in Critically Ill Adult Patients Receiving Extracorporeal Membrane Oxygenation (an ASAP ECMO Study)
Antimicrobial Agents and Chemotherapy · 10.1128/AAC.01377-21
Structure
A two-compartment model, driven by weight and creatinine clearance.
Study population
Critically ill and ECMO patients — International. Fitted to 22 patients and 205 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 41 (IQR 36–53) yr |
| Weight | 76 (IQR 70–90) kg |
| BMI | 26 (IQR 23–29) kg/m² |
| CrCl | 75 (IQR 60–82) mL/min |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 3.20 \cdot \frac{CrCl}{77}
V_1 = 29.73 \cdot \left(\frac{Weight}{80}\right)^{0.75}
V_2 = V_1 \cdot \frac{0.94}{2.11}
Q = V_1 \cdot 0.94
Implementation notes
ECMO model. RRT covariate on clearance excluded.