Chu et al. 2019
Population pharmacokinetics of vancomycin in Chinese patients with augmented renal clearance
Journal of Infection and Public Health · 10.1016/j.jiph.2019.06.016
Structure
A one-compartment model, driven by age.
Study population
Augmented renal clearance patients — China and Asia. Fitted to 95 patients and 186 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 45 (IQR 30–57) yr |
| Weight | 70 (IQR 60–80) kg |
| CrCl | 175.9 (IQR 142.2–198.1) mL/min |
| SCr | 46 (IQR 38–56) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 8.515 \cdot (1 - 0.01175 \cdot (Age - 45)) V_1 = 155.4
Implementation notes
Developed specifically for Chinese patients with augmented renal clearance (CLcr ≥130 mL/min).