Colin et al. 2019
Vancomycin Pharmacokinetics Throughout Life: Results from a Pooled Population Analysis and Evaluation of Current Dosing Recommendations
Clinical Pharmacokinetics · 10.1007/s40262-018-0727-5
Structure
A two-compartment model, driven by postmenstrual age, weight, serum creatinine and age.
Study population
General and Mixed patients — International, Europe, Asia and North America. Fitted to 2,544 patients and 8,300 concentration observations.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 5.312 \cdot \left(\frac{V_1}{42.9}\right)^{0.75} \cdot \frac{F_{mat}}{F_{mat, R}} \cdot \frac{F_{age}}{F_{age, R}} \cdot F_{scr}
F_{mat} = \frac{(PMA/52)^{2.8864}}{0.8932^{2.8864} + (PMA/52)^{2.8864}}
F_{age} = \frac{(PMA/52)^{-2.241}}{61.559^{-2.241} + (PMA/52)^{-2.241}}
F_{scr} = \exp(-0.64856 \cdot (SCr - SCr_{std}))
SCr_{std} = \exp\left(-1.22839 + 0.67190 \cdot \log_{10}\left(\frac{PMA}{52}\right) + 6.27017 \cdot \exp\left(-3.10940 \cdot \frac{PMA}{52}\right)\right)
PMA_R = 35 + \frac{40}{52}
V_1 = 42.9 \cdot \frac{Weight}{70}
V_2 = 41.68 \cdot \frac{Weight}{70}
Q = 3.222 \cdot \left(\frac{V_2}{41.68}\right)^{0.75}
Implementation notes
Pooled lifespan analysis (neonates to elderly). Features sigmoidal maturation/decline for clearance and age-dependent SCr reference.