Deng et al. 2013
Initial dosage regimens of vancomycin for Chinese adult patients based on population pharmacokinetic analysis
International Journal of Clinical Pharmacology and Therapeutics · 10.5414/CP201842
Structure
A one-compartment model, driven by creatinine clearance.
Study population
General patients — China. Fitted to 72 patients and 167 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 54.07 ± 18.36 yr |
| Weight | 61.12 ± 10.7 kg |
| CrCl | 32.09 ± 36.19 mL/min |
| SCr | 0.9 ± 0.51 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = \begin{cases} 0.0654 \cdot CrCl & CrCl < 80 \\ 4.90 & CrCl \ge 80 \end{cases}
V_1 = 47.76
Implementation notes
One-compartment model for Chinese adults. CL is linearly related to CLcr below 80 mL/min and constant above 80 mL/min.