Dolton et al. 2010
Vancomycin pharmacokinetics in patients with severe burn injuries
Burns · 10.1016/j.burns.2009.08.010
Structure
A two-compartment model, driven by weight, creatinine clearance and burns.
Study population
Burn and Mixed patients — Australia. Fitted to 70 patients and 214 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 53 (15–95) yr |
| Weight | 68 (42.5–116) kg |
| CrCl | 100.5 ± 54 mL/min |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 4.7 \cdot \frac{CrCl \cdot \frac{60}{1000}}{6.53}
V_1 = 68.4 \cdot \frac{Weight}{70} + 33.1 \cdot Burn
V_2 = 73.0 \cdot \frac{Weight}{70}
Q = 4.54
Implementation notes
Burns/controls cohort; lean body weight for CrCl. Burn (from tag) adds 33.1 L to central volume; BOV excluded.