Dorajoo et al. 2019
Optimizing Vancomycin Dosing in Chronic Kidney Disease by Deriving and Implementing a Web-Based Tool Using a Population Pharmacokinetics Analysis
Frontiers in Pharmacology · 10.3389/fphar.2019.00641
Structure
A one-compartment model, driven by weight and creatinine clearance.
Study population
Renal impairment patients — Asia and Singapore. Fitted to 80 patients and 170 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 71.7 ± 13 yr |
| Weight | 57.8 ± 15.7 kg |
| BMI | 22.6 ± 5.9 kg/m² |
| CrCl | 33.8 ± 10.3 mL/min |
| SCr | 150.6 ± 73.6 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 1.30 + 0.023 \cdot CrCl V_1 = 1.23 \cdot Weight
Implementation notes
Model developed specifically for CKD patients (CrCl <60 mL/min) not requiring renal replacement therapy.