Garreau et al. 2021
Population Pharmacokinetics and Dosing Simulation of Vancomycin Administered by Continuous Injection in Critically Ill Patient
Antibiotics · 10.3390/antibiotics10101228
Structure
A two-compartment model, driven by ideal body weight and creatinine clearance.
Study population
Critically ill patients — France and Europe. Fitted to 78 patients and 335 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 68.9 ± 12.3 yr |
| Weight | 77.9 ± 20.4 kg |
| BMI | 27.6 ± 7.7 kg/m² |
| CrCl | 50.4 ± 29 mL/min |
| SCr | 1.58 ± 0.86 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 0.79 \cdot e^{\left(\frac{CrCl}{41.4}\right)^{0.5}}
V_1 = 27.3 \cdot e^{\left(\frac{IBW}{64.1}\right)^{1.88}}
V_2 = 61.3
Q = 6.08
Implementation notes
Continuous infusion model for ICU patients. CRRT patients and specific dosage recommendations excluded from this implementation.