Goti et al. 2018
Hospitalized Patients With and Without Hemodialysis Have Markedly Different Vancomycin Pharmacokinetics: A Population Pharmacokinetic Model-Based Analysis
Therapeutic Drug Monitoring · 10.1097/FTD.0000000000000490
Structure
A two-compartment model, driven by weight and creatinine clearance.
Study population
General and Mixed patients — United States and North America. Fitted to 1,812 patients and 2,765 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 57 (17–101) yr |
| Weight | 79 (33–255) kg |
| CrCl | 62 (4–150) mL/min |
| SCr | 1.3 (0.2–16.6) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 4.5 \cdot \left(\frac{CrCl}{120}\right)^{0.8}
CrCl = \frac{(140 - Age) \cdot Weight \cdot [0.85 \text{ if female}]}{72 \cdot SCr_{trunc}}
SCr_{trunc} = \max(SCr,\ 1.0) \text{ if Age} > 65,\ \text{else } SCr
V_1 = 58.4 \cdot \frac{Weight}{70}
V_2 = 38.4
Q = 6.5
Implementation notes
Modified Goti: CrCl truncated at 150 mL/min; hemodialysis covariate excluded. CrCl uses total body weight, with SCr truncated to 1 mg/dL above age 65, as the model was fitted.