Ji et al. 2018
Influences of renal function descriptors on population pharmacokinetic modeling of vancomycin in Chinese adult patients
Acta Pharmacologica Sinica · 10.1038/aps.2017.57
Structure
A one-compartment model, driven by creatinine clearance and age.
Study population
General patients — China and Asia. Fitted to 218 patients and 251 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 78 (42–95) yr |
| Weight | 65 (38–90) kg |
| BMI | 22.31 (12.85–36.89) kg/m² |
| CrCl | 58.02 (5.45–224) mL/min |
| SCr | 75 (24–893) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 2.829 \cdot (1 + 0.00842 \cdot (CrCl - 80)) \cdot \left(\frac{75}{Age}\right)^{0.8143}
V_1 = 52.14
Implementation notes
Model for Chinese adults incorporating age and CrCl. Published age exponent typo (0.08143) corrected to 0.8143 based on Table 3.