Kim AJ et al. 2016
Comparison of the pharmacokinetics of vancomycin in neurosurgical and non-neurosurgical patients
International Journal of Antimicrobial Agents · 10.1016/j.ijantimicag.2016.06.022
Structure
A one-compartment model, driven by creatinine clearance.
Study population
General and Mixed patients — Korea and Asia. Fitted to 132 patients and 359 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 56.3 ± 16.1 yr |
| Weight | 62 ± 12.2 kg |
| CrCl | 95.8 ± 49.8 mL/min |
| SCr | 0.76 ± 0.39 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = \begin{cases} 4.36 \cdot \frac{CrCl}{95.8} & t \le 72h \\ 3.69 \cdot \frac{CrCl}{95.8} & t > 72h \end{cases}
V_1 = \begin{cases} 83.7 & t \le 72h \\ 107.0 & t > 72h \end{cases}
Implementation notes
Time-dependent model (early phase ≤72h). Covariates for neurosurgical status, nephrotoxic drugs, and liver cirrhosis excluded.