Nguyen [Kim AJ] et al. 2025
External Evaluation of Longitudinal Population Pharmacokinetic Models of Vancomycin in Patients With Osteoarticular Infections
Therapeutic Drug Monitoring · 10.1097/FTD.0000000000001303
Structure
A one-compartment model, driven by creatinine clearance.
Study population
General patients — Canada and North America. Fitted to 73 patients and 525 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 56.3 ± 17.5 yr |
| Weight | 81.5 ± 23.4 kg |
| BMI | 28.1 ± 7.1 kg/m² |
| CrCl | 97.3 ± 41.6 mL/min |
| SCr | 1.21 ± 0.51 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = \begin{cases} 4.20 \cdot \frac{CrCl}{95.8} & t \le 72h \\ 3.08 \cdot \frac{CrCl}{95.8} & t > 72h \end{cases}
V_1 = \begin{cases} 50.1 & t \le 72h \\ 51.9 & t > 72h \end{cases}
Implementation notes
Re-estimated Kim AJ 2016 model for osteoarticular infections. Neurosurgical, cirrhosis, and nephrotoxic drug covariates excluded.