Kim YK et al. 2024
Pharmacokinetics of Vancomycin in Healthy Korean Volunteers and Monte Carlo Simulations to Explore Optimal Dosage Regimens in Patients with Normal Renal Function
Antibiotics · 10.3390/antibiotics13100993
Structure
A two-compartment model, driven by weight, age and body surface area.
Study population
General patients — Korea and Asia. Fitted to 12 patients and 60 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 38.5 (IQR 31.5–43.3) yr |
| Weight | 69.5 (IQR 60.7–78.2) kg |
| BMI | 23.3 (IQR 21.4–26.5) kg/m² |
| CrCl | 117 ± 34 mL/min |
| SCr | 0.866 ± 0.192 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 8.83 \cdot \left(\frac{Weight}{69.45}\right)^{1.28} \cdot \left(\frac{Age}{38.5}\right)^{-0.377}
V_1 = 12.9
V_2 = 27.4 \cdot \left(\frac{BSA}{1.80}\right)^{3.09}
Q = 20.2 \cdot \left(\frac{Weight}{69.45}\right)^{2.38}
Implementation notes
Two-compartment model developed in healthy Korean volunteers with normal renal function. Residual widened from the paper's tight 6.94% for stable real-world fitting.