Kovacevic et al. 2020
Population pharmacokinetic model of Vancomycin based on therapeutic drug monitoring data in critically ill septic patients
Journal of Critical Care · 10.1016/j.jcrc.2019.10.012
Structure
A one-compartment model, driven by weight and creatinine clearance.
Study population
Critically ill patients — Europe. Fitted to 73 patients and 146 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 56.9 ± 17 yr |
| Weight | 78.2 ± 14.2 kg |
| BMI | 25.7 ± 4.14 kg/m² |
| CrCl | 80 ± 44 mL/min |
| SCr | 1.23 ± 0.82 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 0.024 \cdot CrCl + 1.93 V_1 = 0.511 \cdot Weight
Implementation notes
Critically ill septic patient model.