Lin et al. 2021
Population pharmacokinetic modeling and clinical application of vancomycin in Chinese patients hospitalized in intensive care units
Scientific Reports · 10.1038/s41598-021-82312-2
Structure
A one-compartment model, driven by weight, age, serum creatinine and burns.
Study population
Critically ill patients — China and Asia. Fitted to 374 patients and 993 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 62 (18–93) yr |
| Weight | 65 (40–90.6) kg |
| SCr | 0.8 (0.32–6.57) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 0.78 + 0.036(DA) - 0.007(SCr) - 0.43(\text{Burn}) + 0.067(Weight) + 0.41(\text{CRRT})
V_1 = 46.47 - 0.04(SCr) - 0.07(Age) + 0.16(Weight)
Implementation notes
ICU model. Burn status set from the burns tag (Lin's severe >50% TBSA category); dopamine and CRRT covariates excluded.