Llopis-Salvia et al. 2006
Population pharmacokinetic parameters of vancomycin in critically ill patients
Journal of Clinical Pharmacy and Therapeutics · 10.1111/j.1365-2710.2006.00762.x
Structure
A two-compartment model, driven by weight and creatinine clearance.
Study population
Critically ill patients — Spain and Europe. Fitted to 50 patients and 337 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 60 (18–81) yr |
| Weight | 60.61 ± 15.55 kg |
| CrCl | 76.28 ± 31.37 mL/min |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 0.015 \cdot Weight + 0.034 \cdot CrCl V_1 = 0.414 \cdot Weight V_2 = 1.32 \cdot Weight Q = 7.48
Implementation notes
Two-compartment model developed in ICU patients.