Masich et al. 2020
Vancomycin Pharmacokinetics in Obese Patients with Sepsis or Septic Shock
Pharmacotherapy · 10.1002/phar.2367
Structure
A one-compartment model, driven by creatinine clearance.
Study population
Obese and Critically ill patients — United States and North America. Fitted to 16 patients and 64 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 62 (30–78) yr |
| Weight | 112.7 (72.6–129.1) kg |
| BMI | 36.1 (30.3–45.8) kg/m² |
| CrCl | 46 (14–123) mL/min |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 3.23 \cdot \left(\frac{CrCl_{ADJWT}}{40}\right)^{0.69}
V_1 = 85.0
Implementation notes
Model developed for obese patients with sepsis/septic shock. Uses adjusted body weight (ADJWT) for Cockcroft-Gault creatinine clearance calculation.