Medellín-Garibay et al. 2016
Pharmacokinetics of vancomycin and dosing recommendations for trauma patients
Journal of Antimicrobial Chemotherapy · 10.1093/jac/dkv372
Structure
A two-compartment model, driven by weight, age, creatinine clearance and furosemide.
Study population
General patients — Spain and Europe. Fitted to 158 patients and 511 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 77 (37–100) yr |
| Weight | 72 (38–110) kg |
| BMI | 27.5 ± 5 kg/m² |
| CrCl | 70.7 ± 51.5 mL/min |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 0.49 \cdot CrCl \cdot \frac{60}{1000}
V_1 = Weight \cdot \begin{cases} 1.07 & Age > 65 \\ 0.74 & Age \le 65 \end{cases}
V_2 = 5.9 \cdot Weight
Q = 0.81
Implementation notes
Two-compartment model for trauma patients. Furosemide effect on clearance excluded.