Oda et al. 2024
Validation and development of population pharmacokinetic model of vancomycin using a real-world database from a nationwide free web application
Journal of Infection and Chemotherapy · 10.1016/j.jiac.2024.05.014
Structure
A two-compartment model, driven by weight and creatinine clearance.
Study population
General and Mixed patients — Japan and Asia. Fitted to 7,146 patients and 13,372 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 70.1 ± 16.5 yr |
| Weight | 55.7 ± 14.8 kg |
| CrCl | 67.5 ± 40.1 mL/min |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 4.9 \cdot \left(\frac{\min(CrCl, 167.8)}{120}\right)^{0.959}
V_1 = 32.1 \cdot \left(\frac{Weight}{60}\right)^{0.532}
V_2 = 58.2 \cdot \left(\frac{Weight}{60}\right)^{0.348}
Q = 8.33
Implementation notes
Large-scale model developed from nationwide web application database with CrCl upper limit.