Okada et al. 2018
Population Pharmacokinetics of Vancomycin in Patients Undergoing Allogeneic Hematopoietic Stem-Cell Transplantation
The Journal of Clinical Pharmacology · 10.1002/jcph.1106
Structure
A two-compartment model, driven by weight and creatinine clearance.
Study population
Transplant patients — Japan and Asia. Fitted to 95 patients and 285 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 49 (17–69) yr |
| Weight | 59.4 (39.4–104.5) kg |
| CrCl | 113 (47–253) mL/min |
| SCr | 0.62 (0.29–1.63) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 4.25 \cdot \left(\frac{CrCl}{113}\right)^{0.70}
V_1 = 39.2 \cdot \left(\frac{Weight}{59.4}\right)^{0.78}
V_2 = 56.1
Q = 1.95
Implementation notes
Model developed specifically for patients undergoing allogeneic hematopoietic stem-cell transplantation with increased volumes of distribution compared to general population.