Parra González et al. 2022
Pharmacokinetics of Vancomycin among Patients with Chemotherapy-Associated Febrile Neutropenia: Which Would Be the Best Dosing to Obtain Appropriate Exposure?
Antibiotics · 10.3390/antibiotics11111523
Structure
A two-compartment model, driven by age and serum creatinine.
Study population
Neutropenia and Hematologic malignancy patients — Colombia and South America. Fitted to 14 patients and 96 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 44 ± 10.4 yr |
| Weight | 60 (IQR 55–67) kg |
| SCr | 0.582 ± 0.081 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 5.2 \cdot \left(\frac{eGFR}{144}\right)^{0.62}
V_1 = 21.22
V_2 = 28.28
Q = 4.99
Implementation notes
Febrile neutropenia model. Uses CKD-EPI 2021 instead of 2009. Residual widened from the paper's tight 2.5% for stable real-world fitting.