Revilla et al. 2010
Vancomycin dosing assessment in intensive care unit patients based on a population pharmacokinetic/pharmacodynamic simulation
British Journal of Clinical Pharmacology · 10.1111/j.1365-2125.2010.03679.x
Structure
A one-compartment model, driven by age, creatinine clearance, serum creatinine and weight.
Study population
Critically ill patients — Spain and Europe. Fitted to 191 patients and 569 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 61.1 ± 16.3 yr |
| Weight | 73 ± 13.3 kg |
| BMI | 26.2 ± 4.1 kg/m² |
| CrCl | 74.7 ± 58 mL/min |
| SCr | 1.4 ± 1 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL_{(mL/min/kg)} = 0.67 \cdot \frac{CrCl}{Weight} + Age^{-0.24}
V_1 = 0.82 \cdot Weight \cdot \begin{cases} 2.49 & SCr_{baseline} > 1.0 \\ 1.0 & SCr_{baseline} \le 1.0 \end{cases}
Implementation notes
One-compartment model developed for adult ICU patients. The volume covariate stratifies patients on their baseline creatinine and is held fixed for the course.