Roberts et al. 2011
Vancomycin Dosing in Critically Ill Patients: Robust Methods for Improved Continuous-Infusion Regimens
Antimicrobial Agents and Chemotherapy · 10.1128/AAC.01708-10
Structure
A one-compartment model, driven by weight and creatinine clearance.
Study population
Critically ill patients — Belgium and Europe. Fitted to 206 patients and 579 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 58.1 ± 14.8 yr |
| Weight | 74.8 ± 15.8 kg |
| BMI | 25.9 ± 5.4 kg/m² |
| CrCl | 90.7 ± 60.4 mL/min |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = CrCl \cdot \frac{4.58 \cdot 1.73}{100 \cdot BSA}
V_1 = 1.53 \cdot Weight
Implementation notes
Continuous infusion model for critically ill septic patients.