Smit et al. 2019
Population pharmacokinetics of vancomycin in obesity: Finding the optimal dose for (morbidly) obese individuals
British Journal of Clinical Pharmacology · 10.1111/bcp.14144
Structure
A three-compartment model, driven by weight and age.
Study population
Obese, General and Mixed patients — Netherlands and Europe. Fitted to 28 patients and 326 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 35.2 (20–55) yr |
| Weight | 104.3 (60–234.6) kg |
| BMI | 37.9 (20.4–65.7) kg/m² |
| CrCl | 135.5 ± 39 mL/min |
| SCr | 0.72 (0.41–1.01) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 5.72 \cdot \left(\frac{Weight}{70}\right)^{0.535}
V_1 = 16.7 \cdot (1 + 0.0136 \cdot (Age - 36.5))
V_2 = 6.98 \cdot \frac{Weight}{70} \cdot (1 + 0.0136 \cdot (Age - 36.5))
V_3 = 19.5
Q_2 = 15.8
Q_3 = 5.21
Implementation notes
Three-compartment model. BMI-dependent IIV on clearance. No renal function covariates - developed in patients with normal renal function only.