Staatz et al. 2005
Population pharmacokinetic modelling of gentamicin and vancomycin in patients with unstable renal function following cardiothoracic surgery
British Journal of Clinical Pharmacology · 10.1111/j.1365-2125.2005.02547.x
Structure
A one-compartment model, driven by weight and creatinine clearance.
Study population
General, Critically ill and Mixed patients — Scotland, United Kingdom and Europe. Fitted to 139 patients and 559 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 66 (17–87) yr |
| Weight | 72.5 (44–112) kg |
| CrCl | 60 (12–172) mL/min |
| SCr | 1.14 (0.51–5.96) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 2.97 \cdot (1 + 0.0205 \cdot (CrCl - 57)) V_1 = 1.24 \cdot Weight
Implementation notes
One-compartment model developed for cardiothoracic surgery patients with unstable renal function.