Thomson et al. 2009
Development and evaluation of vancomycin dosage guidelines designed to achieve new target concentrations
Journal of Antimicrobial Chemotherapy · 10.1093/jac/dkp085
Structure
A two-compartment model, driven by weight and creatinine clearance.
Study population
General and Mixed patients — Scotland, United Kingdom and Europe. Fitted to 398 patients and 1,557 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 66 (16–97) yr |
| Weight | 72 (40–159) kg |
| CrCl | 64 (12–216) mL/min |
| SCr | 1.11 (0.34–6.48) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 2.99 \cdot (1 + 0.0154 \cdot (CrCl - 66)) V_1 = 0.675 \cdot Weight V_2 = 0.732 \cdot Weight Q = 2.28
Implementation notes
Two-compartment model from routine TDM data. CrCl capped at 150 mL/min (capped Thomson) — not in the original 2009 model.