Tong et al. 2026
Improved Prediction of Vancomycin Pharmacokinetics in Patients Receiving Continuous Renal Replacement Therapy Using a Novel Population Model Validated With Real-World Data
Therapeutic Drug Monitoring · 10.1097/FTD.0000000000001432
Structure
A two-compartment model, driven by weight, age and serum creatinine.
Study population
General patients — United States and North America. Fitted to 2,409 patients and 7,264 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 62 (18–100) yr |
| Weight | 89 (28–350) kg |
| BMI | 30 (13–69.6) kg/m² |
| CrCl | 61 (3.1–930) mL/min |
| SCr | 1.5 (0.1–33) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL_{renal} = 4.225 \cdot \left(\frac{FFM}{70}\right)^{0.75} \cdot \left(\frac{AGE}{55}\right)^{-0.4} \cdot \left(\frac{eGFR_{CKD-EPI}}{100}\right)^{0.841}
V_1 = 72.973 \cdot \left(\frac{FFM}{70}\right)^{0.6}
V_2 = 46.306 \cdot \left(\frac{FFM}{70}\right)^{0.6}
Q = 2.438 \cdot \left(\frac{FFM}{70}\right)^{0.75}
Implementation notes
Model developed with CRRT parameters; implemented here for non-RRT patients (CL_CRRT excluded).