Yamamoto et al. 2009
Population pharmacokinetic analysis of vancomycin in patients with gram-positive infections and the influence of infectious disease type
Journal of Clinical Pharmacy and Therapeutics · 10.1111/j.1365-2710.2008.01016.x
Structure
A two-compartment model, driven by weight and creatinine clearance.
Study population
General and Mixed patients — Japan and Asia. Fitted to 100 patients and 311 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 65.4 ± 15.1 yr |
| Weight | 52.6 ± 12.7 kg |
| CrCl | 79.6 ± 41.8 mL/min |
| SCr | 0.79 ± 0.4 mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = \begin{cases} 3.83 & CrCl \ge 85 \\ 0.0322 \cdot CrCl + 0.32 & CrCl < 85 \end{cases}
V_1 = 0.478 \cdot Weight
V_2 = 60.6
Q = 8.81
Implementation notes
Two-compartment model with threshold-based clearance.