Zhang et al. 2024
How to Dose Vancomycin in Overweight and Obese Patients with Varying Renal (Dys)function in the Novel Era of AUC 400-600 mg-h/L-Targeted Dosing
Clinical Pharmacokinetics · 10.1007/s40262-023-01324-5
Structure
A three-compartment model, driven by creatinine clearance, weight and critically ill.
Study population
Obese and Critically ill patients — Netherlands and Europe. Fitted to 230 patients and 1,395 concentration observations.
| Covariate | As reported |
|---|---|
| Age | 70 (23–92) yr |
| Weight | 91.8 (58.6–234.6) kg |
| BMI | 30 (25–65.7) kg/m² |
| CrCl | 74.5 (6–154.9) mL/min |
| SCr | 0.95 (0.26–8.46) mg/dL |
Reported as the source publication gives them — mean ± SD, or median with range or interquartile range.
Equations
The model's structural parameters as Chorus implements them.
LaTeX source
CL = 3.36 \cdot \left(\frac{eGFR}{75}\right)^{0.658} \cdot [1 + 0.0106 \cdot (TBW - 90)] \cdot F_{ICU}
F_{ICU} = 0.845 \text{ if critically ill, else } 1.0
V_1 = 16.7
V_2 = 23.1
V_3 = 83.0
Q_2 = 16.1
Q_3 = 2.44
Implementation notes
Three-compartment overweight/obese model. ICU status (from the ICU tag) lowers clearance 15.5%. CL uses CKD-EPI 2021 eGFR and total body weight.